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5 Shocking New Updates On The Cast Of Netflix's 'Pulse' Medical Drama (Including A Secret Wedding!)

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The highly-anticipated Netflix medical drama, Pulse, is set to redefine the genre with its high-stakes, Miami-based emergency room setting, and its cast is already generating massive buzz across Hollywood. The series, which has a confirmed premiere date of April 3, 2025, marks a major milestone for the streaming giant as its first English-language medical procedural, bringing together a powerhouse ensemble of established stars and rising talents.

The show’s premise—following a group of doctors and nurses as they navigate a chaotic Miami hospital, with the added pressure of a looming hurricane—promises intense, character-driven storytelling. From a surprise A-list wedding to major new film announcements, here is the freshest and most current information on the main cast of Pulse, proving why this show is poised to be Netflix's next big hit.

Meet the Pulse Lifeline: Full Cast Biography and Profile Updates

The core cast of Pulse features five main actors, each bringing a distinct background from major franchises, including the DC Universe, the CW's supernatural world, and Amazon's superhero smash hit. Their recent career moves and personal milestones are as dramatic as the series itself.

Willa Fitzgerald as Dr. Danielle “Danny” Simms

  • Role in Pulse: Dr. Danielle “Danny” Simms. She is expected to be the series' central figure, a brilliant but complicated doctor navigating the pressures of the ER.
  • Date of Birth: January 17, 1992 (Age 33 as of late 2025)
  • Birthplace: Nashville, Tennessee, U.S.
  • Career Highlights: Fitzgerald is widely known for her breakout role as Emma Duval in the horror series Scream: The TV Series (2015–2016). More recently, she gained significant recognition for playing Roscoe Conklin in the first season of the Amazon Prime Video action series Reacher.
  • Latest Updates (2025): Fitzgerald has two major feature films slated for 2025: the psychological drama Beach House and the action film Alarum, where she stars alongside action legend Sylvester Stallone. She is also set to appear in the film adaptation of Colleen Hoover's novel, Regretting You.

Colin Woodell as Dr. Xander Phillips

  • Role in Pulse: Dr. Xander Phillips. A charismatic and skilled doctor, likely serving as a key love interest or professional rival.
  • Date of Birth: December 20, 1991 (Age 34 as of late 2025)
  • Birthplace: San Francisco, California, U.S.
  • Career Highlights: Woodell is a familiar face to fans of supernatural dramas, best known for his recurring role as Aiden in The CW's The Originals, a spin-off of The Vampire Diaries. He also starred in the film The Call of the Wild (2020) and the thriller series The Flight Attendant.
  • Latest Updates (2025): In a major personal update, Woodell married his former The Originals co-star, actress Danielle Campbell, in September 2025, confirming the news shortly before the Pulse premiere buzz began. He was also seen attending the Los Angeles premiere of the HBO Original's "I Love LA" in late 2025.

Justina Machado as Dr. Natalie Cruz

  • Role in Pulse: Dr. Natalie Cruz. Expected to be a senior or attending physician, providing the veteran gravitas to the emergency room.
  • Date of Birth: September 6, 1972 (Age 53 as of late 2025)
  • Birthplace: Chicago, Illinois, U.S.
  • Career Highlights: Machado is a highly respected actress in both comedy and drama. She is celebrated for her long-running role as Vanessa Diaz on the HBO drama Six Feet Under and as Darci Factor on The CW's Jane the Virgin. Her versatility is a major asset to the Pulse ensemble.
  • Latest Updates (2025): Machado was recently honored as a 2025 ¡HOLA! Latina Powerhouse, recognizing her significant contributions and influence in the entertainment industry, further cementing her status as a television icon.

Jessie T. Usher as Sam Elijah

  • Role in Pulse: Sam Elijah. Character details are tightly guarded, but Usher’s background suggests a role with intense dramatic or high-action elements.
  • Career Highlights: Usher is globally recognized for his role as the speedster superhero A-Train in the critically acclaimed Amazon Prime Video series The Boys. He also starred in the film Independence Day: Resurgence.
  • Latest Updates (2025): Usher continues his work on The Boys while also developing an untitled project based on a documentary about a culinary program at a Michigan prison, showcasing his interest in producing and telling diverse stories. He was also a notable attendee at the 2025 Saturn Awards.

Jack Bannon as Tom Cole

  • Role in Pulse: Tom Cole. Likely a British doctor or a character with a mysterious past, given Bannon's previous roles.
  • Career Highlights: Bannon is best known for portraying a young Alfred Pennyworth in the DC Comics prequel series Pennyworth (originally on Epix, now Max). He also had a recurring role as Sam Thursday on the ITV drama series Endeavour.
  • Latest Updates (2025): Bannon's primary focus has been on the transition and conclusion of Pennyworth, making his role in Pulse a fresh step into the fast-paced world of a modern medical procedural, moving away from his period-drama roots.

The Netflix Pulse: Why This Medical Drama is the New Must-Watch

The creation of Pulse is a strategic move by Netflix to capture the audience that loves long-running, emotionally resonant medical procedurals, a genre traditionally dominated by network television hits like Grey’s Anatomy and ER. The show is spearheaded by creator and co-showrunner Zoe Robyn, alongside seasoned television veteran Carlton Cuse, known for his work on Lost and Bates Motel.

The combination of a high-profile cast and proven showrunners is a strong indicator of the series' potential for topical authority. The series is set to provide a fresh, modern take on the genre, focusing on the intense, life-or-death decisions made by young residents in the emergency room.

The unique "Miami hospital facing a hurricane" plot element also elevates the stakes beyond typical medical cases, introducing a natural disaster LSI keyword that promises high-octane drama and a sense of isolation.

From Superheroes to Surgeons: The Cast's Major Career Shifts

One of the most compelling aspects of the Pulse cast is the significant shift in genre for several of its key players. This transition adds a layer of curiosity for fans and provides a wealth of LSI keywords for search engines:

  • Jessie T. Usher (A-Train): Moving from the cynical, satirical world of *The Boys* and its superhero politics to the grounded, life-saving reality of a medical drama is a massive pivot. Fans are eager to see the actor trade his super-speed uniform for scrubs.
  • Jack Bannon (Alfred Pennyworth): Bannon is shedding the tailored suits and espionage of the Batman prequel series *Pennyworth* for the chaos of a modern American ER. His transition from a period drama and action-adventure background to a procedural is a testament to his range.
  • Willa Fitzgerald (Roscoe Conklin): While *Reacher* had dramatic elements, her role in *Pulse* as Dr. Danny Simms is a return to a high-pressure, character-focused series, reminiscent of her early work in *Scream*.

These genre jumps are not just career moves; they are a deliberate attempt to showcase the actors' versatility and draw in established fan bases from the superhero and action universes, providing a strong foundation for the show's success.

What to Expect from the Pulse Premiere on April 3, 2025

The April 3, 2025, premiere date positions Pulse perfectly in the streaming calendar, giving it ample opportunity to dominate the conversation.

The first look images and plot details released by Netflix confirm that the show will focus heavily on the ethical and personal challenges of the residents. Dr. Danny Simms (Willa Fitzgerald) is described as a brilliant but conflicted third-year medical resident whose personal life clashes with her professional duties.

The series will explore themes of mentorship, betrayal, and the brutal reality of the American healthcare system, all set against the visually stunning, yet dramatically volatile, backdrop of Miami. The inclusion of co-showrunner Carlton Cuse suggests a commitment to high production value and complex, season-long story arcs, moving beyond the case-of-the-week format.

With its fresh cast updates—including the surprising Woodell-Campbell wedding, Fitzgerald's major film roles in *Alarum* and *Regretting You*, and Justina Machado's 2025 Latina Powerhouse honor—Pulse is clearly building a strong narrative both on and off-screen. This new English-language medical procedural is poised to be a major streaming event, and fans should mark their calendars for the 2025 debut.

cast of pulse
cast of pulse

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