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The ER Cast: Where Are The Medical Drama’s Biggest Stars Now In 2025?

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The iconic cast of ER continues to make headlines in Hollywood and beyond, over 16 years after the groundbreaking medical drama aired its final episode. As of late December 2025, the original County General crew is experiencing a massive resurgence, sparked by a major 30th-anniversary milestone and a flurry of new, high-profile projects, including a potential on-screen reunion on a brand-new medical show.

From George Clooney’s continued big-screen dominance to Julianna Margulies’ return to the stage and Noah Wyle’s new role as the executive producer of a fresh hospital series, the stars of the longest-running primetime medical drama in U.S. television history are busier than ever. This is the ultimate, up-to-the-minute breakdown of where the ER cast is today and all their latest career endeavors.

The Original Triage Team: Latest Career Updates and Current Projects

The core group of doctors and nurses who launched ER into a global phenomenon have all cemented their places in television history. Their current career paths highlight a diverse range of projects, proving their enduring star power three decades after the show's debut.

  • George Clooney (Dr. Doug Ross): The biggest breakout star of the series, Clooney remains a Hollywood powerhouse. In 2025, he continues to focus on directing and producing major studio films through his company, Smokehouse Pictures, alongside acting in highly anticipated features. He recently reunited with the original cast for a viral photo, sending fans into a frenzy.
  • Julianna Margulies (Nurse Carol Hathaway): Following her Emmy-winning run on The Good Wife, Margulies is back on the stage. In 2025, she is starring in the new Broadway play Left on Tenth, based on Delia Ephron's bestselling memoir. She also appeared in the indie drama Millers in Marriage, which was released in February 2025.
  • Anthony Edwards (Dr. Mark Greene): After his heartbreaking departure from ER, Edwards has maintained a steady career across film and television. In 2024 and 2025, he has been involved in several projects, including the acclaimed miniseries WeCrashed and the film The Man in the White Van, solidifying his reputation as a versatile character actor.
  • Noah Wyle (Dr. John Carter): Wyle is perhaps the most likely to bring the ER spirit back to television. He is the star and an executive producer of the new medical drama series, The Pitt, which premiered recently. Wyle has also taken on new writing and directing roles for the show, and there is significant speculation that he is actively recruiting former ER castmates to join him on the new show.
  • Eriq La Salle (Dr. Peter Benton): La Salle has transitioned successfully behind the camera, focusing heavily on directing and producing. His latest project is the Prime Video police drama series On Call, where he serves as an executive producer and director. He is also set to direct and executive produce the premiere episode of a new CBS FBI series, demonstrating his continued influence in TV production.
  • Sherry Stringfield (Dr. Susan Lewis): One of the original five main cast members, Stringfield has largely stepped away from the spotlight since her final return to ER. Her last major acting credit was in 2017, and she now leads a more private life, which is a significant departure from her high-profile role as the skilled but docile Dr. Lewis.

The Second Wave: From Luka Kovač to Kerry Weaver

As the original cast members began to leave County General, a new set of dynamic characters stepped in, maintaining the show's high quality and emotional intensity. Many of these actors have also gone on to enjoy robust and diverse careers.

The International Stars and Fan Favorites

The mid-to-late seasons of ER introduced some of the most memorable characters, who have since become global stars in their own right.

  • Alex Kingston (Dr. Elizabeth Corday): The British actress, who played the talented surgeon, has remained a prominent figure on both sides of the Atlantic. In a huge 2025 update, Kingston was announced as a contestant on the popular UK reality competition show Strictly Come Dancing. She also continues her fan-favorite role as River Song in the Doctor Who audio dramas and makes frequent appearances at fan conventions, connecting with audiences from both of her major franchises.
  • Goran Visnjic (Dr. Luka Kovač): The Croatian actor has capitalized on his leading man status with numerous film and television roles. Visnjic’s recent film credits include the drama You Were Never Here and the religious film Fatima. He has also appeared in high-profile TV series like Timeless, showcasing his versatility across genres.
  • Maura Tierney (Nurse Abby Lockhart): Tierney, who had a long and beloved run as the complex Abby Lockhart, has had a highly successful post-ER career, including a Golden Globe-winning role in The Affair. Her recent projects include the Showtime series American Rust and the film The Iron Claw, where she received critical praise.
  • Mekhi Phifer (Dr. Gregory Pratt): Known for his charismatic run as Dr. Pratt, Phifer has been consistently working in both film and television. In 2025, he was cast in the upcoming second season of the ABC series High Potential. He also starred in the recently released crime-action thriller Long Gone Heroes.

The Directors and Producers

Several ER actors have leveraged their on-set experience to become successful directors and producers, a true testament to the creative environment of the show.

  • Laura Innes (Dr. Kerry Weaver): Innes, known for her powerful portrayal of the often-controversial Dr. Weaver, has a prolific directing career. She directed several episodes of ER and has since helmed episodes for major shows like The West Wing, How to Get Away with Murder, and The Good Doctor. Her recent acting work includes the 2023 film Daughtering.
  • Paul McCrane (Dr. Robert Romano): McCrane, who played the cantankerous Dr. Romano, is an accomplished television director. His directing credits extend to numerous hit shows, including Scandal, The Fosters, and Grey's Anatomy, continuing his work in the medical drama genre from behind the camera.
  • Gloria Reuben (Jeanie Boulet): Reuben, who starred as the HIV-positive physician assistant Jeanie Boulet, has pursued a career blending acting and music. She recently appeared in the film adaptation of Stephen King's Firestarter and the series City on a Hill, while also continuing to perform as a jazz singer.

The New Generation and Recurring Faces: Where Are They Now?

The latter seasons of ER introduced a new crop of young talent, and the recurring cast provided essential depth to the County General environment. Their current activities further demonstrate the show’s wide-ranging influence.

The following actors, who played key recurring roles, have also maintained active careers:

  • Linda Cardellini (Nurse Samantha Taggart): Cardellini has become a major film and TV star, earning an Emmy nomination for Dead to Me. Her recent film work includes Guardians of the Galaxy Vol. 3 and the animated series My Dad the Bounty Hunter.
  • Scott Grimes (Dr. Archie Morris): Grimes has found a new home in sci-fi and comedy, starring as Lieutenant Gordon Malloy in Seth MacFarlane’s series The Orville. He is also a successful voice actor, notably in the animated show American Dad!.
  • Angela Bassett (Dr. Catherine Banfield): A late-season addition, Bassett is a Hollywood icon. She earned an Oscar nomination for Black Panther: Wakanda Forever and continues to star in the successful series 9-1-1.
  • Ming-Na Wen (Dr. Jing-Mei 'Deb' Chen): Wen is a beloved genre star, known for her roles in Mulan, Agents of S.H.I.E.L.D., and the *Star Wars* universe, where she stars as Fennec Shand in The Mandalorian and The Book of Boba Fett.
  • Sharif Atkins (Dr. Michael Gallant): Atkins has appeared in numerous TV series since ER, including recurring roles on White Collar and The 4400 reboot, maintaining a consistent presence in procedural dramas.
  • Parminder Nagra (Dr. Neela Rasgotra): The British actress has starred in several major TV series, including Alcatraz, Blacklist, and the recent medical drama Maternal, bringing her back to her roots.
  • John Stamos (Dr. Tony Gates): Stamos has continued his long-running career in comedy and drama, starring in the Disney+ series Big Shot and the successful Netflix reboot Fuller House.
  • CCH Pounder (Dr. Angela Hicks): Pounder, a prolific character actress, starred in the successful series NCIS: New Orleans for seven seasons and continues to take on powerful supporting roles in film and television.
  • William H. Macy (Dr. David Morgenstern): The Oscar-nominated actor, who played the early mentor to Dr. Greene, starred in the long-running, critically acclaimed series Shameless and continues to appear in various film projects.

The enduring legacy of ER is not just in its 15 seasons of groundbreaking television, but in the careers of the nearly two dozen actors who have gone on to shape the landscape of modern entertainment. From George Clooney’s film empire to Noah Wyle’s new medical drama, the County General alumni remain some of the most influential figures in the industry today.

er tv show cast
er tv show cast

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